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To further minimize any discomfort: Let the pen reach room temperature before injecting Ensure the alcohol is completely dry before inserting the needle Relax the muscle in the injection area Use a fresh needle every time Try taking some deep breaths before injecting if you’re nervous When it comes to preparing for your first few injections, “I usually remind my clients to stay hydrated, focus on fiber and protein, and ask a partner for help if they need support,” says Sarah Logan, RD